Efficacy of cabazitaxel in mouse models of pediatric brain tumors.

ABSTRACT:

Background

There is an unmet need in the treatment of pediatric brain tumors for chemotherapy that is efficacious, avoids damage to the developing brain, and crosses the blood-brain barrier. These experiments evaluated the efficacy of cabazitaxel in mouse models of pediatric brain tumors.

Methods

The antitumor activity of cabazitaxel and docetaxel were compared in flank and orthotopic xenograft models of patient-derived atypical teratoid rhabdoid tumor (ATRT), medulloblastoma, and central nervous system primitive neuroectodermal tumor (CNS-PNET). Efficacy of cabazitaxel and docetaxel were also assessed in the Smo/Smo spontaneous mouse medulloblastoma tumor model.

Results

This study observed significant tumor growth inhibition in pediatric patient-derived flank xenogra

SUBMITTER: Girard E 

PROVIDER: S-EPMC4483053 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature