Critical functions of RhoB in support of glioblastoma tumorigenesis.

ABSTRACT:

Background

RhoB is a member of the Rho small GTPase family that regulates cytoskeletal dynamics and vesicle trafficking. The RhoB homologs, RhoA and RhoC, have been shown to promote cancer progression and metastasis. In contrast, the functions of RhoB in human cancers are context dependent. Although expression of RhoB inversely correlates with disease progression in several epithelial cancers, recent data suggest that RhoB may support malignant phenotypes in certain cancer types.

Methods

We assessed RhoB protein levels in glioma surgical specimens and patient-derived xenografts. The roles of RhoB in glioblastoma were determined by loss-of-function and gain-of-function assays in vitro and in vivo. The impact on p53 and STAT3 signaling was investigated.

Results

RhoB exp

SUBMITTER: Ma Y 

PROVIDER: S-EPMC4483068 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature