Viral infection of implanted meningeal tumors induces antitumor memory T-cells to travel to the brain and eliminate established tumors.

ABSTRACT:

Background

Leptomeningeal metastases occur in 2%-5% of patients with breast cancer and have an exceptionally poor prognosis. The blood-brain and blood-meningeal barriers severely inhibit successful chemotherapy. We have developed a straightforward method to induce antitumor memory T-cells using a Her2/neu targeted vesicular stomatitis virus. We sought to determine whether viral infection of meningeal tumor could attract antitumor memory T-cells to eradicate the tumors.

Methods

Meningeal implants in mice were studied using treatment trials and analyses of immune cells in the tumors.

Results

This paper demonstrates that there is a blood-meningeal barrier to bringing therapeutic memory T-cells to meningeal tumors. The barrier can be overcome by viral infection of the tum

SUBMITTER: Gao Y 

PROVIDER: S-EPMC4483070 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature