Periostin is a novel therapeutic target that predicts and regulates glioma malignancy.

ABSTRACT:

Background

Periostin is a secreted matricellular protein critical for epithelial-mesenchymal transition and carcinoma metastasis. In glioblastoma, it is highly upregulated compared with normal brain, and existing reports indicate potential prognostic and functional importance in glioma. However, the clinical implications of periostin expression and function related to its therapeutic potential have not been fully explored.

Methods

Periostin expression levels and patterns were examined in human glioma cells and tissues by quantitative real-time PCR and immunohistochemistry and correlated with glioma grade, type, recurrence, and survival. Functional assays determined the impact of altering periostin expression and function on cell invasion, migration, adhesion, and glioma stem

SUBMITTER: Mikheev AM 

PROVIDER: S-EPMC4483094 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature