Identification of 9 serum microRNAs as potential noninvasive biomarkers of human astrocytoma.

ABSTRACT:

Background

Circulating microRNAs (miRNAs) are emerging as promising biomarkers for human cancer. In the current study, we investigated the potential use of serum miRNAs as biomarkers for diagnosis and prognosis in a cohort of Chinese astrocytoma patients.

Methods

An initial screening of the circulating miRNA expression profile was performed on pooled serum samples from 10 preoperative patients and 10 healthy controls using a TaqMan low-density array. The selected serum miRNAs were then validated in 90 preoperative patients and 110 healthy controls who were randomly divided into a training set and a validation set. An additional double-blind test was performed in 50 astrocytomas and 50 controls to assess the serum miRNA-based biomarker accuracy in predicting astrocytoma. The

SUBMITTER: Zhi F 

PROVIDER: S-EPMC4483096 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature