Delayed contrast extravasation MRI: a new paradigm in neuro-oncology.

ABSTRACT:

Background

Conventional magnetic resonance imaging (MRI) is unable to differentiate tumor/nontumor enhancing tissues. We have applied delayed-contrast MRI for calculating high resolution treatment response assessment maps (TRAMs) clearly differentiating tumor/nontumor tissues in brain tumor patients.

Methods

One hundred and fifty patients with primary/metastatic tumors were recruited and scanned by delayed-contrast MRI and perfusion MRI. Of those, 47 patients underwent resection during their participation in the study. Region of interest/threshold analysis was performed on the TRAMs and on relative cerebral blood volume maps, and correlation with histology was studied. Relative cerebral blood volume was also assessed by the study neuroradiologist.

Results

Histological

SUBMITTER: Zach L 

PROVIDER: S-EPMC4483101 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature