Subsequent neoplasms in survivors of childhood central nervous system tumors: risk after modern multimodal therapy.

ABSTRACT:

Background

Multimodal therapy has improved survival for some childhood CNS tumors. However, whether risk for subsequent neoplasms (SNs) also increases is unknown. We report the cumulative incidence of, and risk factors for, SNs after a childhood primary CNS tumor and determine whether treatment that combines radiation therapy (RT) with chemotherapy increases risk for SNs.

Methods

Analyses included 2779 patients with a primary CNS tumor treated at St Jude Children's Research Hospital between 1985 and 2012. Cumulative incidence and standardized incidence ratios (SIRs) were estimated for SNs confirmed by pathology report. Cumulative incidence among the 237 five-year medulloblastoma survivors treated with multimodal therapy (RT + chemotherapy) was compared with a historical coho

SUBMITTER: Tsui K 

PROVIDER: S-EPMC4483102 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature