Biopsy versus partial versus gross total resection in older patients with high-grade glioma: a systematic review and meta-analysis.

ABSTRACT:

Background

Optimal extent of surgical resection (EOR) of high-grade gliomas (HGGs) remains uncertain in the elderly given the unclear benefits and potentially higher rates of mortality and morbidity associated with more extensive degrees of resection.

Methods

We undertook a meta-analysis according to a predefined protocol and systematically searched literature databases for reports about HGG EOR. Elderly patients (≥60 y) undergoing biopsy, subtotal resection (STR), and gross total resection (GTR) were compared for the outcome measures of overall survival (OS), postoperative karnofsky performance status (KPS), progression-free survival (PFS), mortality, and morbidity. Treatment effects as pooled estimates, mean differences (MDs), or risk ratios (RRs) with corresponding 95% co

SUBMITTER: Almenawer SA 

PROVIDER: S-EPMC4483123 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature