Determination of HIV Status in African Adults With Discordant HIV Rapid Tests.

ABSTRACT:

Background

In resource-limited settings, HIV infection is often diagnosed using 2 rapid tests. If the results are discordant, a third tie-breaker test is often used to determine HIV status. This study characterized samples with discordant rapid tests and compared different testing strategies for determining HIV status in these cases.

Methods

Samples were previously collected from 173 African adults in a population-based survey who had discordant rapid test results. Samples were classified as HIV positive or HIV negative using a rigorous testing algorithm that included two fourth-generation tests, a discriminatory test, and 2 HIV RNA tests. Tie-breaker tests were evaluated, including rapid tests (1 performed in-country), a third-generation enzyme immunoassay, and two fourth-g

SUBMITTER: Fogel JM 

PROVIDER: S-EPMC4483143 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature