Digoxin Use and Subsequent Outcomes Among Patients in a Contemporary Atrial Fibrillation Cohort.

ABSTRACT:

Background

Although digoxin has long been used to treat atrial fibrillation (AF) and heart failure (HF), its safety remains controversial.

Objectives

This study sought to describe digoxin use over time in patients with AF who were stratified by the presence or absence of HF, to characterize the predictors of digoxin use and initiation, and to correlate digoxin use with outcomes.

Methods

Longitudinal patterns of digoxin use and its association with a variety of outcomes were assessed in a prospective outpatient registry conducted at 174 U.S. sites with enrollment from June 2010 to August 2011.

Results

Among 9,619 patients with AF and serial follow-up every 6 months for up to 3 years, 2,267 (23.6%) received digoxin at study enrollment, 681 (7.1%) were initiated o

SUBMITTER: Allen LA 

PROVIDER: S-EPMC4483195 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature