Non-thermal plasma treatment altered gene expression profiling in non-small-cell lung cancer A549 cells.

ABSTRACT:

Background

Recent technological advances in atmospheric plasmas have made the creation of non-thermal atmospheric pressure plasma (NTP) possible for utilization in the medical field. Although accumulated evidence suggests that NTP induces cell death in various cancer cell types thus offering a promising alternative treatment strategy, the mechanism underlying its therapeutic effect is not fully understood.

Results

We analyzed relevant signaling cascades associated with the tumor protein p53, in particular the cell cycle arrest, DNA damage as well as the underlying apoptosis pathways. Based on our results, the major effect from plasma exposure was found to be the activation of MAPK and p53 signaling pathways, resulting in changes in gene expression of MEKK, GADD, FOS and JUN.

SUBMITTER: Hou J 

PROVIDER: S-EPMC4483225 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature