Effective Delivery of Endogenous Antioxidants Ameliorates Diabetic Nephropathy.

ABSTRACT:

Background

Diabetic nephropathy (DN) is thought to be partially due to the injury of renal cells and the renal micro-environment by free radicals. Free radial scavenging agents that inhibit free radical damage may well prevent the development of underlying conditions such as mesangial expansion (by inhibiting extracellular matrix expression) in these patients.

Methods

Using techniques for intra-cellular delivery of peptides, we made metallothionein (MT) and superoxide dismutase (SOD), potent endogenous antioxidants, readily transducible into cell membrane and tested their protective effect against the development of DN in OLETF rats. Herein, we study antioxidant peptides for their ability to prevent oxidative damage to primary rat mesangial cells (MCs), which are important c

SUBMITTER: Park Y 

PROVIDER: S-EPMC4483240 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature