Glucocorticosteroids for sepsis: systematic review with meta-analysis and trial sequential analysis.

ABSTRACT:

Introduction

Glucocorticosteroids (steroids) are widely used for sepsis patients. However, the potential benefits and harms of both high and low dose steroids remain unclear. A systematic review of randomised clinical trials with meta-analysis and trial sequential analysis (TSA) might shed light on this clinically important question.

Methods

A systematic review was conducted according to a published protocol and The Cochrane Handbook methodology including meta-analyses, TSA of randomised clinical trials, and external validity estimation (GRADE). Randomised clinical trials evaluating steroids were included for sepsis patients (systemic inflammatory response syndrome, sepsis, severe sepsis or septic shock) aged >18 years. Cochrane Central Register of Controlled Trials (CENTRAL

SUBMITTER: Volbeda M 

PROVIDER: S-EPMC4483251 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature