Active surveillance for prostate cancer: a systematic review of clinicopathologic variables and biomarkers for risk stratification.

ABSTRACT:

Context

Active surveillance (AS) is an important strategy to reduce prostate cancer overtreatment. However, the optimal criteria for eligibility and predictors of progression while on AS are debated.

Objective

To review primary data on markers, genetic factors, and risk stratification for patient selection and predictors of progression during AS.

Evidence acquisition

Electronic searches were conducted in PubMed, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception to April 2014 for original articles on biomarkers and risk stratification for AS.

Evidence synthesis

Patient factors associated with AS outcomes in some studies include age, race, and family history. Multiple studies provide consistent evidence that a lower percentag

SUBMITTER: Loeb S 

PROVIDER: S-EPMC4483277 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature