Mapping the relationship between subgenual cingulate cortex functional connectivity and depressive symptoms across adolescence.

ABSTRACT: Changes in the functional connectivity of the subgenual anterior cingulate cortex (SGC) have been linked with depressive symptoms. The aim of this study was to map this relationship across mid to late adolescence. Employing a longitudinal functional magnetic resonance imaging (fMRI) design, associations between patterns of resting-state SGC functional connectivity and symptoms of depression were examined at two time points in an initial sample of 72 adolescents. Using a region-of-interest approach, these associations were evaluated cross-sectionally and longitudinally. Cross-sectionally, weaker SGC functional connectivity with the posterior cingulate cortex (PCC), angular gyrus and dorsal prefrontal cortex at baseline, and weaker SGC connectivity with the dorsomedial prefrontal cortex (DMP

SUBMITTER: Strikwerda-Brown C 

PROVIDER: S-EPMC4483565 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature