Association of matrix metalloproteinase-1 -519A/G polymorphism with acute coronary syndrome: a meta-analysis.

ABSTRACT: Matrix metalloproteinase-1 (MMP-1) has been demonstrated to play an important role in the development and progression of acute coronary syndrome (ACS). Recent studies have shown that MMP-1 -519A/G (rs1144393) polymorphism is associated with the susceptibility to ACS. However, published studies showed inconsistent results. Therefore, a meta-analysis of eligible studies reporting the association between -519A/G polymorphism and ACS was carried out. A systematic search was conducted using PubMed, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure and Chinese Wan Fang database. Six eligible studies involving 5670 subjects (2868 ACS patients and 2802 healthy controls) were included in this meta-analysis. Overall, this meta-analysis showed a significant association betwe

SUBMITTER: Jia P 

PROVIDER: S-EPMC4483846 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature