Advanced colorectal adenoma related gene expression signature may predict prognostic for colorectal cancer patients with adenoma-carcinoma sequence.

ABSTRACT:

Background

There are still no absolute parameters predicting progression of adenoma into cancer. The present study aimed to characterize functional differences on the multistep carcinogenetic process from the adenoma-carcinoma sequence.

Methods

All samples were collected and mRNA expression profiling was performed by using Agilent Microarray high-throughput gene-chip technology. Then, the characteristics of mRNA expression profiles of adenoma-carcinoma sequence were described with bioinformatics software, and we analyzed the relationship between gene expression profiles of adenoma-adenocarcinoma sequence and clinical prognosis of colorectal cancer.

Results

The mRNA expressions of adenoma-carcinoma sequence were significantly different between high-grade intraepithelia

SUBMITTER: Li B 

PROVIDER: S-EPMC4483896 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature