Association of interleukin-12 gene polymorphisms with cancer susceptibility: a meta-analysis.

ABSTRACT:

Objective

To evaluate the association between interleukin-12 (IL-12) gene polymorphism and cervical cancer susceptibility.

Methods

We comprehensively retrieved the relevant English and Chinese database to collect case-control studies on the association between the IL-12 gene polymorphism and cervical cancer susceptibility. Data were extracted independently by two researchers respectively, the summary data were analyzed using Revman 5.2 software, the association was described using odds ratios (OR) and 95% confidence intervals (95% CI).

Results

According to inclusion and exclusion criteria, 5 case-control studies involving 2552 cervical cancer patients and 2232 healthy controls were included. The meta-analysis results showed that 3'UTR+1188 (rs3212227) polymorphism in

SUBMITTER: Chang SW 

PROVIDER: S-EPMC4483960 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature