Relation between ADIPOQ gene polymorphisms and type 2 diabetes in a Chinese population.

ABSTRACT: OBJECTIVE:We aimed to investigate the relation between adiponectin gene (ADIPOQ) polymorphisms and type 2 diabetes mellitus (T2DM) in a Chinese population. METHODS:The present study included 510 subjects with normal glucose tolerant (NGT) and 510 patients with type 2 diabetic. Five SNPs (rs2241767, rs3821799, rs182052, rs1501299 and rs7627128) were genotyped by TaqMan methods. RESULTS:Of these 5 SNPs, three SNPs (rs1501299, rs182052, and rs7627128) were found to be significantly associated with T2DM. The haplotypes AAT (Construction of rs1501299, rs182052, and rs7627128) was frequent in T2DM patients (OR=2.051, 95% CI: 1.439~2.923, P<0.001), but GAT (Construction of rs1501299, rs182052, and rs7627128) was frequent in the control group (OR=0.65, 95% CI: 0.540~0.805, P<0.001). CONCLUSION:The ADIPOQ gene variants and haplotype were associated with the risk for development of type 2 diabetes.

SUBMITTER: Wang WL 

PROVIDER: S-EPMC4483972 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature