Association between CCR6 and rheumatoid arthritis: a meta-analysis.

ABSTRACT:

Objective

Chemokine (C-C motif) receptor 6 gene (CCR6) polymorphism has been reported to be associated with rheumatoid arthritis (RA) in different ethnic populations. Moreover, its inhibition by monoclonal antibody in mouse model has suppressed arthritis. However, few replication studies have reported conflicting results about this association. Therefore, to establish that CCR6 indeed is a risk factor associated with RA among different ethnic populations, a comprehensive meta-analysis study was conducted.

Methods

PubMed and MEDLINE databases were searched using the term 'CCR6' for all articles published before May 2014. All the replication studies examining the association between CCR6 and RA were reviewed for meta-analysis. Data were summarized using random-effects meta-ana

SUBMITTER: Cheng P 

PROVIDER: S-EPMC4483986 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature