Hypersplenism: an independent risk factor for myocardial remodeling in chronic heart failure patients.

ABSTRACT:

Background

During the progression of chronic heart failure (CHF), decreased cardiac functioning is often associated with congestion in the inferior vena vein, which in turn induces splenomegaly and subsequent hypersplenism. Hypersplenism has been shown to exacerbate endothelial dysfunction and adverse cardiac remodeling in HF mice. However, it is unknown whether this effect also occurs in CHF patients with hypersplenism. Here, we compared different patterns of myocardial remodeling between patients with and without hypersplenism.

Methods

33 CHF patients with hypersplenism were selected and carefully examined. Clinical data and baseline hemogram measurements were included in the evaluation. Another 35 CHF patients were randomly chosen as controls. All patients received formal

SUBMITTER: Tang Y 

PROVIDER: S-EPMC4483994 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature