Association of vitamin d receptor-a gene polymorphisms with coronary heart disease in Han Chinese.

ABSTRACT:

Objective

To assess the association between coronary heart disease (CHD) and vitamin D receptor (VDR) gene polymorphisms in Han Chinese adults.

Methods

A total of 215 CHD patients and 67 controls were recruited. In both groups, the VDR gene single nucleotide polymorphisms (SNP) of Tru9I (rs757343), ApaI (rs7975232), TaqI (rs731236) and FokI (rs2228570) were detected, and the frequencies of VDR genotypes were compared between patients and controls. The relationship between VDR FokI genotype and risk for CHD was assessed by logistic regression analysis after adjusting for age and sex. In addition, the clinical parameters and biochemical characteristics of CHD subgroups were compared according to the VDR FokI polymorphism.

Results

The frequencies of FokI genotypes in CHD

SUBMITTER: He L 

PROVIDER: S-EPMC4484009 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature