Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS).

ABSTRACT:

Rationale

Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and intensive therapy unit mortality but has not been assessed as a risk factor for acute respiratory distress syndrome (ARDS). Causality of these associations has never been demonstrated.

Objectives

To determine if ARDS is associated with vitamin D deficiency in a clinical setting and to determine if vitamin D deficiency in experimental models of ARDS influences its severity.

Methods

Human, murine and in vitro primary alveolar epithelial cell work were included in this study.

Findings

Vitamin D deficiency (plasma 25(OH)D levels <50 nmol/L) was ubiquitous in patients with ARDS and present in the vast majority of patients at risk of developing ARDS following oesophagectomy. In a

SUBMITTER: Dancer RC 

PROVIDER: S-EPMC4484044 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature