Risk of second cancers according to radiation therapy technique and modality in prostate cancer survivors.

ABSTRACT:

Purpose

Radiation therapy (RT) techniques for prostate cancer are evolving rapidly, but the impact of these changes on risk of second cancers, which are an uncommon but serious consequence of RT, are uncertain. We conducted a comprehensive assessment of risks of second cancer according to RT technique (>10 MV vs ≤10 MV and 3-dimensional [3D] vs 2D RT) and modality (external beam RT, brachytherapy, and combined modes) in a large cohort of prostate cancer patients.

Methods and materials

The cohort was constructed using the Surveillance Epidemiology and End Results-Medicare database. We included cases of prostate cancer diagnosed in patients 66 to 84 years of age from 1992 to 2004 and followed through 2009. We used Poisson regression analysis to compare rates of second cancer a

SUBMITTER: Berrington de Gonzalez A 

PROVIDER: S-EPMC4484296 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature