Toxicity of aged gasoline exhaust particles to normal and diseased airway epithelia.

ABSTRACT: Particulate matter (PM) pollution is a leading cause of premature death, particularly in those with pre-existing lung disease. A causative link between particle properties and adverse health effects remains unestablished mainly due to complex and variable physico-chemical PM parameters. Controlled laboratory experiments are required. Generating atmospherically realistic aerosols and performing cell-exposure studies at relevant particle-doses are challenging. Here we examine gasoline-exhaust particle toxicity from a Euro-5 passenger car in a uniquely realistic exposure scenario, combining a smog chamber simulating atmospheric ageing, an aerosol enrichment system varying particle number concentration independent of particle chemistry, and an aerosol deposition chamber physiologically deliver

SUBMITTER: Kunzi L 

PROVIDER: S-EPMC4484354 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature