Using genome-wide measures of coancestry to maintain diversity and fitness in endangered and domestic pig populations.

ABSTRACT: Conservation and breeding programs aim at maintaining the most diversity, thereby avoiding deleterious effects of inbreeding while maintaining enough variation from which traits of interest can be selected. Theoretically, the most diversity is maintained using optimal contributions based on many markers to calculate coancestries, but this can decrease fitness by maintaining linked deleterious variants. The heterogeneous patterns of coancestry displayed in pigs make them an excellent model to test these predictions. We propose methods to measure coancestry and fitness from resequencing data and use them in population management. We analyzed the resequencing data of Sus cebifrons, a highly endangered porcine species from the Philippines, and genotype data from the Pietrain domestic breed. By

SUBMITTER: Bosse M 

PROVIDER: S-EPMC4484394 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature