A meta-analysis for CXCR4 as a prognostic marker and potential drug target in non-small cell lung cancer.

ABSTRACT:

Background

Recent reports have shown that C-X-C chemokine receptor type 4 (CXCR4) is a candidate oncogene in several types of human tumors, including non-small cell lung cancer (NSCLC). However, the correlation between CXCR4 expression and clinicopathological characteristics of NSCLC remains controversial and has not been emphasized. The aim of this study is to quantitatively evaluate the association of CXCR4 expression with the incidence of NSCLC and clinicopathological characteristics by performing a meta-analysis.

Methods

A detailed literature search was carried out for related research publications. Only articles in which CXCR4 expression was detected by immunohistochemical staining were included. Odds ratio (OR) and hazard ratio (HR) with 95% confidence intervals (CIs)

SUBMITTER: Zhang C 

PROVIDER: S-EPMC4484670 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature