TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives.

ABSTRACT:

Background

Thiazide diuretics have been recommended as a first-line antihypertensive treatment, although the choice of 'the right drug in the individual essential hypertensive patient' remains still empirical. Essential hypertension is a complex, polygenic disease derived from the interaction of patient's genetic background with the environment. Pharmacogenomics could be a useful tool to pinpoint gene variants involved in antihypertensive drug response, thus optimizing therapeutic advantages and minimizing side effects.

Methods and results

We looked for variants associated with blood pressure response to hydrochlorothiazide over an 8-week follow-up by means of a genome-wide association analysis in two Italian cohorts of never-treated essential hypertensive patients: 343 samp

SUBMITTER: Chittani M 

PROVIDER: S-EPMC4484731 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature