Increased Systemic and Plaque Inflammation in ABCA1 Mutation Carriers With Attenuation by Statins.

ABSTRACT:

Objective

We previously demonstrated that subjects with functional ATP-binding cassette (ABC) A1 mutations have increased atherosclerosis, which has been attributed to the role of ABCA1 in reverse cholesterol transport. More recently, a proinflammatory effect of Abca1 deficiency was shown in mice, potentially contributing to atherogenesis. In this study, we investigated whether ABCA1 deficiency was associated with proinflammatory changes in humans.

Approach and results

Thirty-one heterozygous, 5 homozygous ABCA1 mutation carriers, and 21 matched controls were studied. (18)Fluorodeoxyglucose positron emission tomography with computed tomographic scanning was performed in a subset of carriers and controls to assess arterial wall inflammation (target:background ratio). Heterozy

SUBMITTER: Bochem AE 

PROVIDER: S-EPMC4484788 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature