State of the Art on the Evidence Base in Cardiac Regenerative Therapy: Overview of 41 Systematic Reviews.

ABSTRACT:

Objectives

To provide a comprehensive appraisal of the evidence from secondary research on cardiac regenerative therapy.

Study design and setting

Overview of systematic reviews of controlled clinical trials concerning stem cell administration or mobilization in patients with cardiovascular disease.

Results

After a systematic database search, we short-listed 41 reviews (660 patients). Twenty-two (54%) reviews focused on acute myocardial infarction (AMI), 19 (46%) on chronic ischemic heart disease (IHD) or heart failure (HF), 29 (71%) on bone marrow-derived stem-cells (BMSC), and 36 (88%) to randomized trials only. Substantial variability among reviews was found for validity (AMSTAR score: median 9 [minimum 3]; 1st quartile 9; 3rd quartile 10; maximum 11), effect estima

SUBMITTER: Peruzzi M 

PROVIDER: S-EPMC4484838 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature