Complement activity is associated with disease severity in multifocal motor neuropathy.

ABSTRACT:

Objective

To investigate whether high innate activity of the classical and lectin pathways of complement is associated with multifocal motor neuropathy (MMN) and whether levels of innate complement activity or the potential of anti-GM1 antibodies to activate the complement system correlate with disease severity.

Methods

We performed a case-control study including 79 patients with MMN and 79 matched healthy controls. Muscle weakness was documented with Medical Research Council scale sum score and axonal loss with nerve conduction studies. Activity of the classical and lectin pathways of complement was assessed by ELISA. We also determined serum mannose-binding lectin (MBL) concentrations and polymorphisms in the MBL gene (MBL2) and quantified complement-activating properties

SUBMITTER: Vlam L 

PROVIDER: S-EPMC4484896 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature