Risk Factors for Recurrent Urinary Tract Infection and Renal Scarring.

ABSTRACT:

Objectives

To identify risk factors for recurrent urinary tract infection (UTI) and renal scarring in children who have had 1 or 2 febrile or symptomatic UTIs and received no antimicrobial prophylaxis.

Methods

This 2-year, multisite prospective cohort study included 305 children aged 2 to 71 months with vesicoureteral reflux (VUR) receiving placebo in the RIVUR (Randomized Intervention for Vesicoureteral Reflux) study and 195 children with no VUR observed in the CUTIE (Careful Urinary Tract Infection Evaluation) study. Primary exposure was presence of VUR; secondary exposures included bladder and bowel dysfunction (BBD), age, and race. Outcomes were recurrent febrile or symptomatic urinary tract infection (F/SUTI) and renal scarring.

Results

Children with VUR had high

SUBMITTER: Keren R 

PROVIDER: S-EPMC4485012 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature