Filtration markers as predictors of ESRD and mortality in Southwestern American Indians with type 2 diabetes.

ABSTRACT:

Background

A growing number of serum filtration markers are associated with mortality and end-stage renal disease (ESRD) in adults. Whether β-trace protein (BTP) and β2-microglobulin (B2M) are associated with these outcomes in adults with type 2 diabetes is not known.

Study design

Longitudinal cohort study.

Setting & participants

250 Pima Indians with type 2 diabetes (69% women; mean age, 42 years; mean diabetes duration, 11 years).

Predictors

Serum BTP, B2M, and glomerular filtration rate measured by iothalamate clearance (mGFR) or estimated using creatinine (eGFRcr) or cystatin C level (eGFRcys).

Outcomes & measurements

Incident ESRD and all-cause mortality through December 2013. HRs were reported per interquartile range decrease of the inverse of BTP

SUBMITTER: Foster MC 

PROVIDER: S-EPMC4485524 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature