Fibroblast growth factor 23 and sudden versus non-sudden cardiac death: the Cardiovascular Health Study.

ABSTRACT:

Background

Elevated fibroblast growth factor 23 (FGF-23) concentrations are associated with greater risk of cardiovascular events and mortality, especially among people with chronic kidney disease (CKD). Because individuals with CKD are at an increased risk of sudden cardiac death (SCD), we sought to understand whether FGF-23 level is a stronger risk factor for SCD versus non-SCD.

Study design

Cohort study.

Setting & participants

3,244 participants 65 years or older in the community-based Cardiovascular Health Study.

Predictor

Plasma FGF-23 concentrations.

Outcomes

We assessed SCD and non-SCD in these analyses. SCD was adjudicated rigorously and was defined as a sudden pulseless condition of cardiac origin in a previously stable person occurring out of h

SUBMITTER: Deo R 

PROVIDER: S-EPMC4485528 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature