Long-term Outcomes of Cytomegalovirus Retinitis in the Era of Modern Antiretroviral Therapy: Results from a United States Cohort.

ABSTRACT:

Purpose

To describe the long-term outcomes of patients with cytomegalovirus (CMV) retinitis and AIDS in the modern era of combination antiretroviral therapy.

Design

Prospective, observational cohort study.

Participants

Patients with AIDS and CMV retinitis.

Methods

Immune recovery, defined as a CD4+ T-cell count >100 cells/μl for ≥3 months.

Main outcome measures

Mortality, visual impairment (visual acuity <20/40), and blindness (visual acuity ≤20/200) on logarithmic visual acuity charts and loss of visual field on quantitative Goldmann perimetry.

Results

Patients without immune recovery had a mortality of 44.4/100 person-years (PYs) and a median survival of 13.5 months after the diagnosis of CMV retinitis, whereas those with immune recovery had a m

SUBMITTER: Jabs DA 

PROVIDER: S-EPMC4485590 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature