Subcutaneous nerve activity is more accurate than heart rate variability in estimating cardiac sympathetic tone in ambulatory dogs with myocardial infarction.

ABSTRACT:

Background

We recently reported that subcutaneous nerve activity (SCNA) can be used to estimate sympathetic tone.

Objective

The purpose of this study was to test the hypothesis that left thoracic SCNA is more accurate than heart rate variability (HRV) in estimating cardiac sympathetic tone in ambulatory dogs with myocardial infarction (MI).

Methods

We used an implanted radiotransmitter to study left stellate ganglion nerve activity (SGNA), vagal nerve activity (VNA), and thoracic SCNA in 9 dogs at baseline and up to 8 weeks after MI. HRV was determined based on time-domain, frequency-domain, and nonlinear analyses.

Results

The correlation coefficients between integrated SGNA and SCNA averaged 0.74 (95% confidence interval [CI] 0.41-1.06) at baseline and 0.82 (9

SUBMITTER: Chan YH 

PROVIDER: S-EPMC4485600 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature