Immune checkpoint blockade in microsatellite instable colorectal cancers: Back to the clinic.

ABSTRACT: The active Th1/CTL immune microenvironment of Microsatellite Instable colorectal cancer (CRC) is counterbalanced by up-regulated expression of multiple immune checkpoints, suggesting that defective mismatch repair may be a biomarker to select CRC patients for treatment with checkpoint inhibitors. This hypothesis is currently being tested in two clinical trials.

SUBMITTER: Housseau F 

PROVIDER: S-EPMC4485714 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature