CD20⁺ T cells have a predominantly Tc1 effector memory phenotype and are expanded in the ascites of patients with ovarian cancer.

ABSTRACT: Recently, a small subset of T cells that expresses the B cell marker CD20 has been identified in healthy volunteers and in patients with rheumatoid arthritis and multiple sclerosis. The origin of these CD20-positive T cells as well as their relevance in human disease remains unclear. Here, we identified that after functional B cell/T cell interaction CD20 molecules are transferred to the cell surface of T cells by trogocytosis together with the established trogocytosis marker HLA-DR. Further, the presence of CD20 on isolated CD20⁺ T cells remained stable for up to 48h of ex vivo culture. These CD20⁺ T cells almost exclusively produced IFNγ (∼70% vs. ∼20% in the CD20^- T cell population) and were predominantly (CD8⁺) effector memory T cells

SUBMITTER: de Bruyn M 

PROVIDER: S-EPMC4485721 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature