Cervical (pre)neoplastic microenvironment promotes the emergence of tolerogenic dendritic cells via RANKL secretion.

ABSTRACT: The progression of genital human papillomavirus (HPV) infections into preneoplastic lesions suggests that infected/malignant cells are not adequately recognized by the immune system. In this study, we demonstrated that cervical/vulvar cancer cells secrete factor(s) that affect both the maturation and function of dendritic cells (DC) leading to a tolerogenic profile. Indeed, DC cocultured with cancer cell lines display both a partially mature phenotype after lipopolysaccharide (LPS) maturation and an altered secretory profile (IL-10^high and IL-12p70^low). In addition, tumor-converted DC acquire the ability to alter T-cell proliferation and to induce FoxP3⁺ suppressive T cells from naive CD4⁺ T cells. Among the immunosuppressive factors implicated i

SUBMITTER: Demoulin SA 

PROVIDER: S-EPMC4485731 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature