Immune independent crosstalk between lymphoma and myeloid suppressor CD14⁺HLA-DR^low/neg monocytes mediates chemotherapy resistance.

ABSTRACT: We have previously reported a novel phenotype of myeloid suppressors in lymphoma patients characterized by a loss of HLA-DR expression on monocytes, CD14⁺HLA-DR^low/neg. These cells were directly immunosuppressive and were associated with poor clinical outcome. In this study, we found that lymphoma tumors could have more than 30% of their tumor occupied by CD14⁺ cells. This intimate spatial connection suggested substantial cell-cell communication. We examined cross talk between monocytes from healthy volunteers (normal) and lymphoma cells in co-culture to identify the mechanisms and consequences of these interactions. Normal CD14⁺HLA-DR⁺ monocytes lost their HLA-DR expression after co-culture with lymphoma cells. Lymphoma-converted CD14

SUBMITTER: Zhang ZJ 

PROVIDER: S-EPMC4485750 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature