B7-H6-mediated downregulation of NKp30 in NK cells contributes to ovarian carcinoma immune escape.

ABSTRACT: In this study the phenotype and function of tumor-associated NK cells from peritoneal fluids of a selected cohort of patients with seropapillary ovarian carcinoma were analyzed. In > 50% of these patients, the expression of the activating receptor NKp30 in tumor-associated NK cells was substantially reduced as compared to autologous peripheral blood (PB) NK cells. The impaired expression of this receptor was associated with the presence of one of its cellular ligands (B7-H6), which was detectable as a surface/cytosolic molecule in tumor cells and as a soluble molecule in the peritoneal fluid. NK cells from patients expressing this NKp30low phenotype displayed an impaired interferon-gamma (IFNγ) production and cytolytic function when tested against target cells expressing surface B7-H6. Our

SUBMITTER: Pesce S 

PROVIDER: S-EPMC4485754 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature