Local Salmonella immunostimulation recruits vaccine-specific CD8 T cells and increases regression of bladder tumor.

ABSTRACT: The efficacy of antitumoral responses can be increased using combinatorial vaccine strategies. We recently showed that vaccination could be optimized by local administration of diverse molecular or bacterial agents to target and augment antitumoral CD8 T cells in the genital mucosa (GM) and increase regression of cervical cancer in an animal model. Non muscle-invasive bladder cancer is another disease that is easily amenable to local therapies. In contrast to data obtained in the GM, in this study we show that intravesical (IVES) instillation of synthetic toll-like receptor (TLR) agonists only modestly induced recruitment of CD8 T cells to the bladder. However, IVES administration of Ty21a, a live bacterial vaccine against typhoid fever, was much more effective and increased the number of

SUBMITTER: Domingos-Pereira S 

PROVIDER: S-EPMC4485756 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature