Myeloid <i>STAT3</i> promotes formation of colitis-associated colorectal cancer in mice.

ABSTRACT: Myeloid cells lacking STAT3 promote antitumor responses of NK and T cells but it is unknown if this crosstalk affects development of autochthonous tumors. We deleted STAT3 in murine myeloid cells (STAT3^Δm) and examined the effect on the development of autochthonous colorectal cancers (CRCs). Formation of Azoxymethane/Dextransulfate (AOM/DSS)-induced CRCs was strongly suppressed in STAT3^Δm mice. Gene expression profiling showed strong activation of T cells in the stroma of STAT3^Δm CRCs. Moreover, STAT3^Δm host mice were better able to control the growth of transplanted MC38 colorectal tumor cells which are known to be killed in a T cell-dependent manner. These data suggest that myeloid cells lacking STAT3 control formation of C

SUBMITTER: Pathria P 

PROVIDER: S-EPMC4485776 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature