Rapid generation of NY-ESO-1-specific CD4⁺ T_HELPER1 cells for adoptive T-cell therapy.

ABSTRACT: Tumor-associated antigens such as NY-ESO-1 are expressed in a variety of solid tumors but absent in mature healthy tissues with the exception of germline cells. The immune system anti-cancer attack is mediated by cell lysis or induction of growth arrest through paralysis of tumor cells, the latter of which can be achieved by tumor-specific CD4⁺, IFNγ-producing T_Helper type 1 (T_H1) cells. Translation of these immune-mediated mechanisms into clinical application has been limited by availability of immune effectors, as well as the need for complex in vitro protocols and regulatory hurdles. Here, we report a procedure to generate cancer-testis antigen NY-ESO-1-targeting CD4⁺ T_H1 cells in vitro for cancer immunotherapy in the

SUBMITTER: Kayser S 

PROVIDER: S-EPMC4485840 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature