Ubiquitin-specific proteases are differentially expressed throughout the Schistosoma mansoni life cycle.

ABSTRACT:

Background

The ubiquitination process can be reversed by deubiquitinating enzymes (DUBs). These proteases are involved in ubiquitin processing, in the recovery of modified ubiquitin trapped in inactive forms, and in the recycling of ubiquitin monomers from polyubiquitinated chains. The diversity of DUB functions is illustrated by their number and variety of their catalytic domains with specific 3D architectures. DUBs can be divided into five subclasses: ubiquitin C-terminal hydrolases (UCHs), ubiquitin-specific proteases (USPs or UBPs), ovarian tumour proteases (OTUs), Machado-Joseph disease proteases (MJDs) and JAB1/MPN/Mov34 metalloenzymes (JAMMs).

Methods

Considering the role that the ubiquitin-proteasome system has been shown to play during the development of Schistosoma

SUBMITTER: Pereira RV 

PROVIDER: S-EPMC4485857 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature