Peptide HIV-1 integrase inhibitors from HIV-1 gene products.

ABSTRACT: Anti-HIV peptides with inhibitory activity against HIV-1 integrase (IN) have been found in overlapping peptide libraries derived from HIV-1 gene products. In a strand transfer assay using IN, inhibitory active peptides with certain sequential motifs related to Vpr- and Env-derived peptides were found. The addition of an octa-arginyl group to the inhibitory peptides caused a remarkable inhibition of the strand transfer and 3'-end-processing reactions catalyzed by IN and significant inhibition against HIV replication.

SUBMITTER: Suzuki S 

PROVIDER: S-EPMC4486249 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature