Association Between NRAS and BRAF Mutational Status and Melanoma-Specific Survival Among Patients With Higher-Risk Primary Melanoma.

ABSTRACT:

Importance

NRAS and BRAF mutations in melanoma inform current treatment paradigms, but their role in survival from primary melanoma has not been established. Identification of patients at high risk of melanoma-related death based on their primary melanoma characteristics before evidence of recurrence could inform recommendations for patient follow-up and eligibility for adjuvant trials.

Objective

To determine tumor characteristics and survival from primary melanoma by somatic NRAS and BRAF status.

Design, setting, and participants

A population-based study with a median follow-up of 7.6 years (through 2007), including 912 patients from the United States and Australia in the Genes, Environment, and Melanoma (GEM) Study, with first primary cutaneous melanoma diagnosed in

SUBMITTER: Thomas NE 

PROVIDER: S-EPMC4486299 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature