A Photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase.
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ABSTRACT:
SUBMITTER: Nollmann FI
PROVIDER: S-EPMC4486325 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
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A Photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase.
Nollmann Friederike I FI Heinrich Antje K AK Brachmann Alexander O AO Morisseau Christophe C Mukherjee Krishnendu K Casanova-Torres Ángel M ÁM Strobl Frederic F Kleinhans David D Kinski Sebastian S Schultz Katharina K Beeton Michael L ML Kaiser Marcel M Chu Ya-Yun YY Phan Ke Long L Thanwisai Aunchalee A Bozhüyük Kenan A J KA Chantratita Narisara N Götz Friedrich F Waterfield Nick R NR Vilcinskas Andreas A Stelzer Ernst H K EH Goodrich-Blair Heidi H Hammock Bruce D BD Bode Helge B HB
Chembiochem : a European journal of chemical biology 20150225 5
Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence. ...[more]
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