TMFoldRec: a statistical potential-based transmembrane protein fold recognition tool.

ABSTRACT:

Background

Transmembrane proteins (TMPs) are the key components of signal transduction, cell-cell adhesion and energy and material transport into and out from the cells. For the deep understanding of these processes, structure determination of transmembrane proteins is indispensable. However, due to technical difficulties, only a few transmembrane protein structures have been determined experimentally. Large-scale genomic sequencing provides increasing amounts of sequence information on the proteins and whole proteomes of living organisms resulting in the challenge of bioinformatics; how the structural information should be gained from a sequence.

Results

Here, we present a novel method, TMFoldRec, for fold prediction of membrane segments in transmembrane proteins. TMFoldRec

SUBMITTER: Kozma D 

PROVIDER: S-EPMC4486421 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature