An efficient and mild oxidant for the synthesis of s-tetrazines.

ABSTRACT: PhI(OAc)₂ serves as a mild and effective oxidant for the synthesis of s-tetrazine derivatives- molecules of emerging significance to the field of bioorthogonal chemistry. This reagent serves as a complementary oxidant to harsher nitrous reagents. Use of PhI(OAc)₂ improves the synthesis of 5-amino-di(pyridin-2-yl)-s-tetrazine, a molecule that has been broadly used for cellular imaging and nuclear medicine. The generality of PhI(OAc)₂ as the oxidant for tetrazine synthesis is demonstrated for nine tetrazines in 75-98% yield.

SUBMITTER: Selvaraj R 

PROVIDER: S-EPMC4486492 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature